Completed one project supported by UTP to study in laboratory scale the effects of wettability alteration by different low salinity water compositions in Berea sandstone rock through using brine of different ion compositions and salinities. Measurements were performed on a set of 31 sandstone core slices primarily saturated with formation water and then aged in crude oil at 80° C and ambient pressure. All slices were removed from oil and aged with different low salinity water and formation brine at same conditions. The low salinity water consisted of 30 samples of different compositions with concentrations ranging from 500 to 6500 ppm. The formation water contained high concentration of magnesium and calcium divalent ions (i.e., Mg⁺²and Ca⁺²) at 130,000ppm. The examination of wettability alteration was performed by using the sessile drop method at specified ranges of time. The results revealed that significant change in wettability was observed with the low salinity water composition of potassium and sodium monovalent ions (i.e., K⁺and Na⁺) as compared to the divalent cations of Mg⁺²and Ca⁺². In addition to that, we investigated also the effect of different Total Acid Number (TAN) and Total Base Number (TBN) on wettability alteration during foam flooding. In this work we managed to propose a new mechanism of low salinity water called MIE-RS, which could open the gate to study the wettability alteration using low salinity flooding.