{"id":29,"date":"2016-10-10T06:58:29","date_gmt":"2016-10-10T06:58:29","guid":{"rendered":"http:\/\/staffpages.uofk.edu\/samar-yousif\/?page_id=29"},"modified":"2016-10-10T06:58:29","modified_gmt":"2016-10-10T06:58:29","slug":"research-abstract","status":"publish","type":"page","link":"https:\/\/staffpages.uofk.edu\/samar-yousif\/?page_id=29","title":{"rendered":"Research Abstract"},"content":{"rendered":"<ul>\n<li>Selectively releasing anticancer dimer conjugates were designed utilizing acid labile linkers. Two linkers were studied; well known cis-aconityl and novel furan derivative. Computational Chemistry techniques were performed in order to study the mechanism of acid assisted chemical hydrolysis of drug-linker bond, as well as testing the selective release. The technique used was transition state modeling and energy barrier calculation usingMOPAC2009.<\/li>\n<li>Chemical synthesis of conjugates was performed after which structure characterization and <em>invitro <\/em>testing of drug release at various pH were conducted using1DNMR.<\/li>\n<\/ul>\n<p>Capability of drug conjugates to overcome anticancer drug resistance was tested via docking against P-glycoprotein usingGlide.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Selectively releasing anticancer dimer conjugates were designed utilizing acid labile linkers. Two linkers were studied; well known cis-aconityl and novel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"page-publications.php","meta":{"footnotes":""},"class_list":["post-29","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29"}],"version-history":[{"count":1,"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":31,"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=\/wp\/v2\/pages\/29\/revisions\/31"}],"wp:attachment":[{"href":"https:\/\/staffpages.uofk.edu\/samar-yousif\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}