• Selectively releasing anticancer dimer conjugates were designed utilizing acid labile linkers. Two linkers were studied; well known cis-aconityl and novel furan derivative. Computational Chemistry techniques were performed in order to study the mechanism of acid assisted chemical hydrolysis of drug-linker bond, as well as testing the selective release. The technique used was transition state modeling and energy barrier calculation usingMOPAC2009.
• Chemical synthesis of conjugates was performed after which structure characterization and invitro testing of drug release at various pH were conducted using1DNMR.

Capability of drug conjugates to overcome anticancer drug resistance was tested via docking against P-glycoprotein usingGlide.